Apical phosphatidylserine externalization in auditory hair cells.

  title={Apical phosphatidylserine externalization in auditory hair cells.},
  author={Xiaorui Shi and Peter G. Gillespie and Alfred L. Nuttall},
  journal={Molecular membrane biology},
  volume={24 1},
In hair cells of the inner ear, phosphatidylserine (PS), detected with fluorescent annexin V labeling, was rapidly exposed on the external leaflet of apical plasma membranes upon dissection of the organ of Corti. PS externalization was unchanged by caspase inhibition, suggesting that externalization did not portend apoptosis or necrosis. Consistent with that conclusion, mitochondrial membrane potential and hair-cell nuclear structure remained normal during externalization. PS externalization… CONTINUE READING