Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells.

@article{Mitchell2004ApicalMA,
  title={Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells.},
  author={Graham Howard Mitchell and Alan W. Thomas and G Margos and Anton Richard Dluzewski and Lawrence Howard Bannister},
  journal={Infection and immunity},
  year={2004},
  volume={72 1},
  pages={154-8}
}
Apical membrane antigen 1 (AMA-1) of Plasmodium merozoites is established as a candidate molecule for inclusion in a human malaria vaccine and is strongly conserved in the genus. We have investigated its function in merozoite invasion by incubating Plasmodium knowlesi merozoites with red cells in the presence of a previously described rat monoclonal antibody (MAb R31C2) raised against an invasion-inhibitory epitope of P. knowlesi AMA-1 and then fixing the material for ultrastructural analysis… CONTINUE READING
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