Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II.

@article{Zimmerman2010ApicalCA,
  title={Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II.},
  author={Sandra G Zimmerman and Lauren M. Thorpe and Vilma R Medrano and Carolyn A Mallozzi and Brooke M. McCartney},
  journal={Developmental biology},
  year={2010},
  volume={340 1},
  pages={54-66}
}
The tumor suppressor Adenomatous polyposis coli (APC) is a negative regulator of Wnt signaling and functions in cytoskeletal organization. Disruption of human APC in colonic epithelia initiates benign polyps that progress to carcinoma following additional mutations. The early events of polyposis are poorly understood, as is the role of canonical Wnt signaling in normal epithelial architecture and morphogenesis. To determine the consequences of complete loss of APC in a model epithelium, we… CONTINUE READING

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