Apical and basolateral membrane mechanisms that regulate pHi in bovine retinal pigment epithelium.

@article{Kenyon1997ApicalAB,
  title={Apical and basolateral membrane mechanisms that regulate pHi in bovine retinal pigment epithelium.},
  author={Elizabeth Kenyon and Arvydas Maminishkis and Doreen Joseph and Sheldon S. Miller},
  journal={The American journal of physiology},
  year={1997},
  volume={273 2 Pt 1},
  pages={
          C456-72
        }
}
pH regulation was studied in fresh explant bovine retinal pigment epithelium-choroid using the pH-sensitive dye 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein and intracellular microelectrodes. Acid recovery was HCO3 dependent, inhibited by apical amiloride and apical or basal 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), and required apical and basal Na. Alkali recovery was HCO3 dependent and inhibitable by apical or basal DIDS. Three apical and two basolateral transporters were… CONTINUE READING

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