Apical and basolateral membrane H+ extrusion mechanisms in inner stripe of rabbit outer medullary collecting duct.

@article{Hays1990ApicalAB,
  title={Apical and basolateral membrane H+ extrusion mechanisms in inner stripe of rabbit outer medullary collecting duct.},
  author={Steven R. Hays and Robert J. Alpern},
  journal={The American journal of physiology},
  year={1990},
  volume={259 4 Pt 2},
  pages={F628-35}
}
To examine mechanisms of H+ extrusion in the inner stripe of outer medullary collecting duct (OMCDIS), cell pH (pHi) was measured microfluorometrically in in vitro perfused tubules by use of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. In total absence of luminal and peritubular Na+, pHi recovery from an acid load (NH3/NH+4 pulse) occurred at an initial rate of 0.13 +/- 0.02 pH units/min, whereas in the presence of 135 mM peritubular Na+, pHi recovered at 1.40 +/- 0.28 pH units/min. Na… CONTINUE READING
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