Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1.

@article{Peterson2006ApiaceousVC,
  title={Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1.},
  author={Sabrina Peterson and Johanna W. Lampe and Theo K. Bammler and Kerstin Gross-Steinmeyer and David L. Eaton},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2006},
  volume={44 9},
  pages={
          1474-84
        }
}
In humans, apiaceous vegetables (carrots, parsnips, celery, parsley, etc.) inhibit cytochrome P-450 1A2, a biotransformation enzyme known to activate several procarcinogens, including aflatoxin B1 (AFB). We evaluated eight phytochemicals from apiaceous vegetables for effects on human cytochrome P-450 1A2 (hCYP1A2) activity using a methoxyresorufin O-demethylase (MROD) assay and a trp-recombination assay. Saccharomyces cerevisiae was used for heterologous CYP1A2 expression and this yeast strain… CONTINUE READING
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