Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

@article{Ikegami1978AphidicolinPM,
  title={Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α},
  author={Susumu Ikegami and Takahiko Taguchi and Mochihiko Ohashi and Masahiko Oguro and Hiroshi Nagano and Yoshitake Mano},
  journal={Nature},
  year={1978},
  volume={275},
  pages={458-460}
}
THE study of the control of DNA synthesis would be helped if a variety of chemicals which influenced DNA synthesis in various ways was available. We have searched for chemicals which prevent mitotic division of sea urchin embryos, which requires DNA synthesis, but do not prevent meiotic divisions of starfish oocytes, which are independent of DNA synthesis1. Aphidicolin2 (I) is one such compound. Furthermore, recent experiments have shown that aphidicolin selectively inhibits the activity of DNA… CONTINUE READING
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