Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.

Abstract

Gamma-Secretase cleaves the Amyloid Precursor Protein (APP) in its transmembrane domain, releasing the amyloid peptide Abeta. Abeta is the main constituent of the amyloid plaques in the brains of patients suffering from Alzheimer's disease. Several other type I integral membrane proteins are also cleaved by this protease. Recent work indicates that gamma… (More)

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@article{Strooper2003Aph1PA, title={Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.}, author={Bart De Strooper}, journal={Neuron}, year={2003}, volume={38 1}, pages={9-12} }