Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells.

@article{Hashimoto2006ApelinSM,
  title={Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells.},
  author={Tatsuo Hashimoto and Minoru Kihara and Junji Ishida and Nozomi Imai and Shin-Ichiro Yoshida and Yoshiyuki Toya and Akiyoshi Fukamizu and Hitoshi Kitamura and Satoshi Umemura},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 6},
  pages={1267-72}
}
OBJECTIVE Physiological roles of apelin and its specific receptor APJ signaling were investigated in vascular smooth muscle cells (VSMCs). The present study determined whether apelin activates myosin light chain (MLC), a major regulatory event in initiating smooth muscle contraction. METHODS AND RESULTS To assess MLC activation, we performed Western blot and immunohistochemical studies using an antibody against the phospho-MLC. In VSMCs, apelin induces the phosphorylation of MLC in a… CONTINUE READING