Apelin receptor homodimer-oligomers revealed by single-molecule imaging and novel G protein-dependent signaling

@inproceedings{Cai2017ApelinRH,
  title={Apelin receptor homodimer-oligomers revealed by single-molecule imaging and novel G protein-dependent signaling},
  author={Xin Cai and Bo Bai and Rumin Zhang and Chunmei Wang and Jinghua Chen},
  booktitle={Scientific reports},
  year={2017}
}
The apelin receptor (APJ) belongs to family A of the G protein-coupled receptors (GPCRs) and is a potential pharmacotherapeutic target for heart failure, hypertension, and other cardiovascular diseases. There is evidence APJ heterodimerizes with other GPCRs; however, the existence of APJ homodimers and oligomers remains to be investigated. Here, we measured APJ monomer-homodimer-oligomer interconversion by monitoring APJ dynamically on cells and compared their proportions, spatial arrangement… CONTINUE READING
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