Apelin protects sarcoplasmic reticulum function and cardiac performance in ischaemia-reperfusion by attenuating oxidation of sarcoplasmic reticulum Ca2+-ATPase and ryanodine receptor.

@article{Wang2013ApelinPS,
  title={Apelin protects sarcoplasmic reticulum function and cardiac performance in ischaemia-reperfusion by attenuating oxidation of sarcoplasmic reticulum Ca2+-ATPase and ryanodine receptor.},
  author={Chen Wang and Nan Liu and Ronghua Luan and Yan Li and Dongjuan Wang and Wei Zou and Ying Xing and Ling Jie Tao and Feng Cao and Haichang Wang},
  journal={Cardiovascular research},
  year={2013},
  volume={100 1},
  pages={114-24}
}
AIMS Apelin, an endogenous cytokine, has a number of biological effects on the cardiovascular system, including a cardioprotective effect and calcium modulation. Because the intracellular calcium abnormality is considered to play an important role in cardiac dysfunction induced by ischaemia-reperfusion (I/R), the aim of this study was to examine the effects of apelin-13 on I/R-induced changes in cardiac performance and sarcoplasmic reticulum (SR) function. METHODS AND RESULTS Isolated rat… CONTINUE READING
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