Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells.

@article{MelgarLesmes2010ApelinMT,
  title={Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells.},
  author={Pedro Melgar-Lesmes and Gregori Casals and Montserrat Pauta and Josefa Ros and Vedrana Reichenbach and Ram{\'o}n Bataller and Manuel Morales-Ruiz and Wladimiro Jim{\'e}nez},
  journal={Endocrinology},
  year={2010},
  volume={151 11},
  pages={5306-14}
}
UNLABELLED Apelin is a peptide with relevant functions in angiogenesis and inflammation. Recent studies have demonstrated that apelin is overexpressed in hepatic stellate cells (HSCs) of cirrhotic rats. Moreover, patients with cirrhosis show high circulating levels of this peptide. We evaluated the role of endogenous apelin system in fibrogenesis-related gene induction in human HSCs. Messenger expression and immunolocalization of apelin were analyzed in human cirrhotic liver and in control… CONTINUE READING

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