Apelin is a potent activator of tumour neoangiogenesis

  title={Apelin is a potent activator of tumour neoangiogenesis},
  author={Sonia Caroline Sorli and Sophie Le Gonidec and Bernard Knibiehler and Yves Audigier},
Our laboratory has previously shown that apelin is mitogenic for endothelial cells. We have postulated that apelin represents an angiogenic factor secreted by tumour cells in order to promote the formation of new vessels necessary for tumour growth. We first demonstrate that apelin and its receptor are not expressed by the mouse TS/A mammary carcinoma cells. We therefore established clones of this tumoral cell type stably overexpressing the apelin cDNA (TS/A-apelin clones). Comparison of the in… CONTINUE READING
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Apelin receptor

  • Y. Audigier
  • AfCS Nature Molecule Pages: doi:10.1038/mp…
  • 2006
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Therapeutic potential of interfering with apelin signalling

  • SC Sorli, L van den Berghe, B Masri, B Knibiehler, Y. Audigier
  • Drug Discov Today
  • 2006
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