Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse.

@article{Chen2014ApelinIT,
  title={Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse.},
  author={Hong Chen and Jianshuang Li and Lihua Jiao and Robert Bob Petersen and Jiong Li and Anlin Peng and Ling Zheng and Kun Huang},
  journal={The Journal of physiology},
  year={2014},
  volume={592 3},
  pages={505-21}
}
Diabetic nephropathy is the primary cause of end-stage renal disease. Increasing numbers of patients are suffering from this disease and therefore novel medications and therapeutic approaches are urgently needed. Here, we investigated whether apelin-13, the most active member of the adipokine apelin group, could effectively suppress the development of nephropathy in Akita mouse, a spontaneous type 1 diabetic model. Apelin-13 treatment decreased diabetes-induced glomerular filtration rate… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…