Apelin impairs myogenic response to induce diabetic nephropathy in mice.

@article{Zhang2018ApelinIM,
  title={Apelin impairs myogenic response to induce diabetic nephropathy in mice.},
  author={Jia Zhang and Jiming Yin and Yangjia Wang and Bin Li and Xiangjun Zeng},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2018},
  volume={32 8},
  pages={
          4315-4327
        }
}
The cause of the invalid reaction of smooth muscle cells to mechanical stimulation that results in a dysfunctional myogenic response that mediates the disruption of renal blood flow (RBF) in patients with diabetes is debatable. The present study revealed that increased apelin concentration in serum of diabetic mice neutralized the myogenic response mediated by apelin receptor (APJ) and resulted in increased RBF, which promoted the progression of diabetic nephropathy. The results showed that… CONTINUE READING
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