Apelin decreases the SR Ca2+ content but enhances the amplitude of [Ca2+]i transient and contractions during twitches in isolated rat cardiac myocytes.

@article{Wang2008ApelinDT,
  title={Apelin decreases the SR Ca2+ content but enhances the amplitude of [Ca2+]i transient and contractions during twitches in isolated rat cardiac myocytes.},
  author={Chen Wang and Jun-feng Du and Feng Wu and Hai-Chang Wang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 6},
  pages={H2540-6}
}
Apelin has been reported to have a positive inotropic action in the isolated rat heart. However, the effect of apelin on sarcoplasmic reticulum (SR) Ca2+ content and its influence on intracellular Ca2+ transient during excitation-contraction coupling remains poorly understood. In the present study, we determined the effect of apelin on Ca2+ transient and contractions in isolated rat cardiomyocytes. When compared with control, treatment with apelin caused a 55.7 +/- 13.9% increase in sarcomere… CONTINUE READING
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