Apelin and its receptor control heart field formation during zebrafish gastrulation.

@article{Zeng2007ApelinAI,
  title={Apelin and its receptor control heart field formation during zebrafish gastrulation.},
  author={Xin-Xin I Zeng and Thomas P. Wilm and Diane S. Sepich and Lilianna Solnica-Krezel},
  journal={Developmental cell},
  year={2007},
  volume={12 3},
  pages={391-402}
}
The vertebrate heart arises during gastrulation as cardiac precursors converge from the lateral plate mesoderm territories toward the embryonic midline and extend rostrally to form bilateral heart fields. G protein-coupled receptors (GPCRs) mediate functions of the nervous and immune systems; however, their roles in gastrulation remain largely unexplored. Here, we show that the zebrafish homologs of the Agtrl1b receptor and its ligand, Apelin, implicated in physiology and angiogenesis, control… CONTINUE READING

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