Apelin-13 attenuates cisplatin-induced cardiotoxicity through inhibition of ROS-mediated DNA damage and regulation of MAPKs and AKT pathways.

@article{Zhang2017Apelin13AC,
  title={Apelin-13 attenuates cisplatin-induced cardiotoxicity through inhibition of ROS-mediated DNA damage and regulation of MAPKs and AKT pathways.},
  author={Pu Zhang and Lu-Hua Yi and Guang-Yuan Meng and Huan-Yi Zhang and Hai-Hui Sun and Lian-Qun Cui},
  journal={Free radical research},
  year={2017},
  volume={51 5},
  pages={
          449-459
        }
}
Platinum-based chemotherapy represents one of the most effective ways in combating human cancers. However, the cardiotoxicity subsequent severely limited its clinical application. Increased evidences indicate that oxidative stress plays a crucial role in the pathological process of platinum-induced cardiotoxicity. It is reported that apelin-13 a bioactive peptide has the scavenging capacity of free radical, and it has the potential to regulate the cardiovascular system. Hence, the potential of… CONTINUE READING

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