Apelin-13 attenuates cisplatin-induced cardiotoxicity through inhibition of ROS-mediated DNA damage and regulation of MAPKs and AKT pathways

@article{Zhang2017Apelin13AC,
  title={Apelin-13 attenuates cisplatin-induced cardiotoxicity through inhibition of ROS-mediated DNA damage and regulation of MAPKs and AKT pathways},
  author={P. Zhang and Lu-Hua Yi and Guangyuan Meng and H. Zhang and Hai-Hui Sun and Lianqun Cui},
  journal={Free Radical Research},
  year={2017},
  volume={51},
  pages={449 - 459}
}
  • P. Zhang, Lu-Hua Yi, +3 authors Lianqun Cui
  • Published 2017
  • Biology, Medicine
  • Free Radical Research
  • Abstract Platinum-based chemotherapy represents one of the most effective ways in combating human cancers. However, the cardiotoxicity subsequent severely limited its clinical application. Increased evidences indicate that oxidative stress plays a crucial role in the pathological process of platinum-induced cardiotoxicity. It is reported that apelin-13 a bioactive peptide has the scavenging capacity of free radical, and it has the potential to regulate the cardiovascular system. Hence, the… CONTINUE READING
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