Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury

@article{Simpkin2007Apelin13AA,
  title={Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury},
  author={James C. Simpkin and Prof. Derek M. Yellon and Sean M Davidson and Shiang Yong Lim and Abigail M. Wynne and Christopher C. T. Smith},
  journal={Basic Research in Cardiology},
  year={2007},
  volume={102},
  pages={518-528}
}
Protection against myocardial ischemia-reperfusion (I/R) injury involves activation of phosphatidylinositol-3-OH kinase (PI3K)- Akt/protein kinase B and p44/42 mitogen-activated protein kinase (MAPK), components of the reperfusion injury salvage kinase (RISK) pathway. The adipocytokine, apelin, activates PI3K-Akt and p44/42 in various tissues and we, therefore, hypothesised that it might demonstrate cardioprotective activity. Employing both in vivo (open-chest) and in vitro (Langendorff and… CONTINUE READING
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