Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion

@article{Pisarenko2014Apelin12AI,
  title={Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion},
  author={Oleg Pisarenko and Vadim Z. Lankin and Galina G. Konovalova and Larisa Serebryakova and Valentin Shulzhenko and Alexander A. Timoshin and O. V. Tskitishvili and Yu. A. Pelogeykina and Irina Studneva},
  journal={Molecular and Cellular Biochemistry},
  year={2014},
  volume={391},
  pages={241 - 250}
}
Abstract This study investigated the effects of peptide apelin-12 (H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH, A12) and its novel structural analog (H-(NαMe)Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Nle-Pro-Phe-OH, AI) on myocardial antioxidant enzyme activities, lipid peroxidation, and reactive oxygen species formation in ex vivo and in vivo models of myocardial ischemia/reperfusion (I/R) injury. Isolated working rat hearts were subjected to global ischemia and reperfusion. Infusion of 140… 
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