Apelin–APJ induces ICAM-1, VCAM-1 and MCP-1 expression via NF-κB/JNK signal pathway in human umbilical vein endothelial cells

@article{Lu2012ApelinAPJII,
  title={Apelin–APJ induces ICAM-1, VCAM-1 and MCP-1 expression via NF-κB/JNK signal pathway in human umbilical vein endothelial cells},
  author={Ying Lu and Xiao Hua Zhu and Gan-xiong Liang and Rong-rong Cui and Yuan Liu and Shan-Shan Wu and Qiu-hua Liang and Guan-Ying Liu and Yi Jiang and Xiao-Bo Liao and Hui Xie and Hou-de Zhou and Xian-ping Wu and Ling-Qing Yuan and Er-yuan Liao},
  journal={Amino Acids},
  year={2012},
  volume={43},
  pages={2125-2136}
}
Apelin receptor (APJ) deficiency has been reported to be preventive against atherosclerosis. However, the mechanism of this effect remains unknown. In this study, quantitative real-time RT-PCR, Western blotting and ELISA analyses revealed a significant increase in the expression of intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs) treated with apelin. Inhibitors… CONTINUE READING

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