Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain.

@article{Zou2007Ape1RH,
  title={Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain.},
  author={Gang-Ming Zou and Anqi Luo and April Reed and Mark R Kelley and Mervin C. Yoder},
  journal={Blood},
  year={2007},
  volume={109 5},
  pages={1917-22}
}
Ape1 is a molecule with dual functions in DNA repair and redox regulation of transcription factors. In Ape1-deficient mice, embryos do not survive beyond embryonic day 9, indicating that this molecule is required for normal embryo development. Currently, direct evidence of the role of Ape1 in regulating hematopoiesis is lacking. We used the embryonic stem (ES) cell differentiation system and an siRNA approach to knockdown Ape1 gene expression to test the role of Ape1 in hematopoiesis… CONTINUE READING

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Knockdown of Shp-2 by siRNA on mouse embryonic stem cell derived EB cells affects hematopoietic development

  • GM Zou, RJ Chan, WC Shelley, MC. Yoder
  • Stem Cells
  • 2006

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