Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival.

@article{Paridaen2009Apc1IR,
  title={Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival.},
  author={Judith T.M.L. Paridaen and Catherine Danesin and Abu Tufayal Elas and Sandra G. P. van de Water and Corinne Houart and Danica Živkovi{\'c}},
  journal={Developmental biology},
  year={2009},
  volume={331 2},
  pages={
          101-12
        }
}
The tumor suppressor Apc1 is an intracellular antagonist of the Wnt/beta-catenin pathway, which is vital for induction and patterning of the early vertebrate brain. However, its role in later brain development is less clear. Here, we examined the mechanisms underlying effects of an Apc1 zygotic-effect mutation on late brain development in zebrafish. Apc1 is required for maintenance of established brain subdivisions and control of local organizers such as the isthmic organizer (IsO). Caudal… CONTINUE READING
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