Apatinib resensitizes cisplatin-resistant non-small cell lung carcinoma A549 cell through reversing multidrug resistance and suppressing ERK signaling pathway.

  • Z-L Liu, B-J Jin, +4 authors B. Wu
  • Published 2017 in
    European review for medical and pharmacological…

Abstract

OBJECTIVE To observe the reversal effect of apatinib on the resistance to cisplatin (DDP) of A549/cisplatin (A549/DDP) cells and its relevant mechanism. MATERIALS AND METHODS A549/DDP cells were treated with the control method, apatinib alone, DDP alone and DDP combined with apatinib. The cell proliferation was detected by the 3-(4,5-Dimethylthiazol-2-yl… (More)
DOI: 10.26355/eurrev_201712_13922

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