Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies

@article{Bortolon2018ApathyIS,
  title={Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies},
  author={C. Bortolon and A. Macgregor and D. Capdevielle and S. Raffard},
  journal={Neuropsychologia},
  year={2018},
  volume={118},
  pages={22-33}
}
Apathy is a multidimensional symptom composed of cognitive, behavioral, and emotional facets including impaired motivation and reduced goal-directed behavior. Apathy belongs to schizophrenia's negative symptomatology which has received increased attention over the last years including a growing interest in the assessment and the consequences of apathy. Nevertheless, the pathological mechanisms are still insufficiently explored as well as the multidimensional aspect of this symptom. The aim of… Expand
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Methods Citations
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26 Citations

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Apathy and Striatal Gray Matter Patterns in Schizophrenia and Huntington’s Disease
Apathy is a symptom of many neurodegenerative and neuropsychiatric disorders, such as Huntington's disease and schizophrenia. Apathy is often conceptualized as a combination of three domains,… Expand
Pathophysiology of negative symptom dimensions of schizophrenia – Current developments and implications for treatment
TLDR
It is concluded that such multi-level frameworks are key for the development of new biological and psychosocial treatments and may advance progress towards an individualized treatment of negative symptoms of schizophrenia. Expand
A transnosographic approach of negative symptoms pathophysiology in schizophrenia and depressive disorders
TLDR
Pathophysiological hypotheses are specific to each dimension of negative symptoms and overlap across diagnostic boundaries, possibly underpinning the observed clinical continuum. Expand
Detecting Apathy in Older Adults with Cognitive Disorders Using Automatic Speech Analysis.
TLDR
Correlations between apathy sub-scales and features revealed a relation between temporal aspects of speech and the subdomains of reduction in interest and initiative, as well as between prosody features and the affective domain. Expand
Updating Apathy: Using Research Domain Criteria to Inform Clinical Assessment and Diagnosis of Disorders of Motivation.
TLDR
Although apathy syndromes have been validated, defining potentially distinct disorders of motivation will require additional research to better delineate etiology and pathogenesis, predictive validators, reliable diagnostic methods, treatments, and demonstrations of use for these diagnostic proposals. Expand
Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia
TLDR
Investigation of functional connectivity during rest in patients with schizophrenia and with healthy individuals and whether observed functional alterations are related to the psychopathology of patients provides further evidence for a role DMN alterations might play in schizophrenia and especially in negative symptoms such as apathy. Expand
Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia
TLDR
Investigating the functional connectivity during rest in patients with schizophrenia and healthy individuals and exploring whether observed functional alterations are related to the psychopathology of patients provides further evidence for a role DMN alterations might play in schizophrenia and especially in negative symptom such as apathy. Expand
Apathetic symptoms and white matter integrity after traumatic brain injury
TLDR
The results highlight the relevance of white matter integrity measures in initial assessment after TBI and its relationship with apathetic manifestations in the chronic phase. Expand
Visuospatial and Sensory Integration Tasks in Patients With Schizophrenia or Schizoaffective Disorder: Relationship to Body Mass Index and Smoking
TLDR
The hypothesis that subtle cerebral cortical abnormalities detected with specific NSSs tests may be related to some aspects of metabolic and motivational function in patients with schizophrenia/schizoaffective disorder is supported. Expand
Drugs Based on NMDAR Hypofunction Hypothesis in Schizophrenia
TLDR
This work aimed to provide perspectives for scientists who sought therapeutic strategies for negative symptoms and cognitive dysfunction in schizophrenia based on the NMDAR hypofunction hypothesis and analyzed the unsatisfactory outcomes of these clinical studies according to the improved glutamate hypothesis that has been revealed in animal models. Expand
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