Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies

@article{Bortolon2018ApathyIS,
  title={Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies},
  author={Catherine Bortolon and Alexandra Macgregor and Delphine Capdevielle and St{\'e}phane Raffard},
  journal={Neuropsychologia},
  year={2018},
  volume={118},
  pages={22-33}
}
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34 Citations

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The literature reviewed shows that apathy is a multi-dimensional clinical construct with a current definition and validated diagnostic criteria and that there is a patent lack of RCTs on the efficiency of current therapeutic options.
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Updating Apathy: Using Research Domain Criteria to Inform Clinical Assessment and Diagnosis of Disorders of Motivation.
TLDR
Although apathy syndromes have been validated, defining potentially distinct disorders of motivation will require additional research to better delineate etiology and pathogenesis, predictive validators, reliable diagnostic methods, treatments, and demonstrations of use for these diagnostic proposals.
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Investigation of functional connectivity during rest in patients with schizophrenia and with healthy individuals and whether observed functional alterations are related to the psychopathology of patients provides further evidence for a role DMN alterations might play in schizophrenia and especially in negative symptoms such as apathy.
Apathetic symptoms and white matter integrity after traumatic brain injury
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The results highlight the relevance of white matter integrity measures in initial assessment after TBI and its relationship with apathetic manifestations in the chronic phase.
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The hypothesis that subtle cerebral cortical abnormalities detected with specific NSSs tests may be related to some aspects of metabolic and motivational function in patients with schizophrenia/schizoaffective disorder is supported.
Psychometric properties of the BIRT Motivation Questionnaire (BMQ), a self-measure of avolition in individuals with schizophrenia.
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References

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Assessing apathy: The use of the Apathy Evaluation Scale in first episode psychosis
Different Apathy Profile in Behavioral Variant of Frontotemporal Dementia and Alzheimer's Disease: A Preliminary Investigation
TLDR
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Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits
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An alteration of these circuitry caused a lack of insight, a reduction of decision-making strategies, and a reduced speedness in action decision, major responsible for apathy.
The association of neurocognitive impairment with diminished expression and apathy in schizophrenia
Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment
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