Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies

@article{Bortolon2018ApathyIS,
  title={Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies},
  author={C. Bortolon and A. Macgregor and D. Capdevielle and S. Raffard},
  journal={Neuropsychologia},
  year={2018},
  volume={118},
  pages={22-33}
}
Apathy is a multidimensional symptom composed of cognitive, behavioral, and emotional facets including impaired motivation and reduced goal-directed behavior. Apathy belongs to schizophrenia's negative symptomatology which has received increased attention over the last years including a growing interest in the assessment and the consequences of apathy. Nevertheless, the pathological mechanisms are still insufficiently explored as well as the multidimensional aspect of this symptom. The aim of… Expand
Apathy and Striatal Gray Matter Patterns in Schizophrenia and Huntington’s Disease
Apathy is a symptom of many neurodegenerative and neuropsychiatric disorders, such as Huntington's disease and schizophrenia. Apathy is often conceptualized as a combination of three domains,Expand
Pathophysiology of negative symptom dimensions of schizophrenia – Current developments and implications for treatment
TLDR
It is concluded that such multi-level frameworks are key for the development of new biological and psychosocial treatments and may advance progress towards an individualized treatment of negative symptoms of schizophrenia. Expand
A transnosographic approach of negative symptoms pathophysiology in schizophrenia and depressive disorders
TLDR
Pathophysiological hypotheses are specific to each dimension of negative symptoms and overlap across diagnostic boundaries, possibly underpinning the observed clinical continuum. Expand
Detecting Apathy in Older Adults with Cognitive Disorders Using Automatic Speech Analysis.
TLDR
Correlations between apathy sub-scales and features revealed a relation between temporal aspects of speech and the subdomains of reduction in interest and initiative, as well as between prosody features and the affective domain. Expand
Updating Apathy: Using Research Domain Criteria to Inform Clinical Assessment and Diagnosis of Disorders of Motivation.
TLDR
Although apathy syndromes have been validated, defining potentially distinct disorders of motivation will require additional research to better delineate etiology and pathogenesis, predictive validators, reliable diagnostic methods, treatments, and demonstrations of use for these diagnostic proposals. Expand
Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia
TLDR
Investigation of functional connectivity during rest in patients with schizophrenia and with healthy individuals and whether observed functional alterations are related to the psychopathology of patients provides further evidence for a role DMN alterations might play in schizophrenia and especially in negative symptoms such as apathy. Expand
Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia
TLDR
Investigating the functional connectivity during rest in patients with schizophrenia and healthy individuals and exploring whether observed functional alterations are related to the psychopathology of patients provides further evidence for a role DMN alterations might play in schizophrenia and especially in negative symptom such as apathy. Expand
Apathetic symptoms and white matter integrity after traumatic brain injury
TLDR
The results highlight the relevance of white matter integrity measures in initial assessment after TBI and its relationship with apathetic manifestations in the chronic phase. Expand
Visuospatial and Sensory Integration Tasks in Patients With Schizophrenia or Schizoaffective Disorder: Relationship to Body Mass Index and Smoking
TLDR
The hypothesis that subtle cerebral cortical abnormalities detected with specific NSSs tests may be related to some aspects of metabolic and motivational function in patients with schizophrenia/schizoaffective disorder is supported. Expand
Drugs Based on NMDAR Hypofunction Hypothesis in Schizophrenia
TLDR
This work aimed to provide perspectives for scientists who sought therapeutic strategies for negative symptoms and cognitive dysfunction in schizophrenia based on the NMDAR hypofunction hypothesis and analyzed the unsatisfactory outcomes of these clinical studies according to the improved glutamate hypothesis that has been revealed in animal models. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 140 REFERENCES
The anatomy of apathy: A neurocognitive framework for amotivated behaviour
TLDR
It is argued that motivated behaviour requires a willingness to work, to keep working, and to learn what is worth working for, and that deficits in any one or more of these processes can lead to the clinical syndrome of apathy. Expand
The Lille Apathy Rating Scale (LARS): Exploring its psychometric properties in schizophrenia
TLDR
The findings show that the LARS has satisfactory psychometric properties when used in a different setting than the original version, and is a promising instrument to examine apathy in schizophrenia through a multidimensional framework. Expand
Neural correlates of apathy in patients with neurodegenerative disorders, acquired brain injury, and psychiatric disorders
TLDR
Results suggest that abnormalities within fronto-striatal circuits are most consistently associated with apathy across the different pathological conditions, and abnormalities within the inferior parietal cortex were also linked to apathy. Expand
Apathy, cognitive deficits and functional impairment in schizophrenia
TLDR
The findings confirm that apathy has a stronger relationship to functional impairment than cognitive deficits on a cross-sectional basis in schizophrenia, and suggest that apathetic and executive dysfunction might represent different manifestations of the same syndrome, probably sharing a common neural substrate. Expand
A Multidimensional Approach to Apathy after Traumatic Brain Injury
TLDR
A new multidimensional framework is proposed that takes into account the various mechanisms at play in the facets of apathy, including not only cognitive factors, especially executive, but also affective factors and aspects related to personal identity. Expand
Assessing apathy: The use of the Apathy Evaluation Scale in first episode psychosis
TLDR
This study shows that the AES-C measures more than one dimension, and the main factor, the Apathy subscale, can be used to assess apathy in first episode psychosis patients in the ongoing work of refining the subdomains of the negative syndrome. Expand
Different Apathy Profile in Behavioral Variant of Frontotemporal Dementia and Alzheimer's Disease: A Preliminary Investigation
TLDR
The preliminary findings support the hypothesis that apathy is a complex phenomenon, whose clinical expression is conditioned by the site of anatomical damage, and may help in differentiating bvFTD from AD. Expand
[Apathy in Parkinson's disease].
TLDR
It is very important to do a differential diagnosis with the depression and the cognitive deficit since the therapeutic approach is different and specific scales to measure this symptom should be included in the evaluation protocols of cognitive function in Parkinson's disease. Expand
Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits
TLDR
An alteration of these circuitry caused a lack of insight, a reduction of decision-making strategies, and a reduced speedness in action decision, major responsible for apathy. Expand
The association of neurocognitive impairment with diminished expression and apathy in schizophrenia
TLDR
It is found that diminished expression significantly related to neurocognitive impairment, while severity of apathy symptoms was not directly associated with neurocognition, which indicates that cognitive remediation therapy might be helpful to ameliorate expressive deficits. Expand
...
1
2
3
4
5
...