Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies

@article{Bortolon2018ApathyIS,
  title={Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies},
  author={Catherine Bortolon and Alexandra Macgregor and Delphine Capdevielle and St{\'e}phane Raffard},
  journal={Neuropsychologia},
  year={2018},
  volume={118},
  pages={22-33}
}

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References

SHOWING 1-10 OF 148 REFERENCES
Different Apathy Profile in Behavioral Variant of Frontotemporal Dementia and Alzheimer's Disease: A Preliminary Investigation
TLDR
The preliminary findings support the hypothesis that apathy is a complex phenomenon, whose clinical expression is conditioned by the site of anatomical damage, and may help in differentiating bvFTD from AD.
Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits
TLDR
An alteration of these circuitry caused a lack of insight, a reduction of decision-making strategies, and a reduced speedness in action decision, major responsible for apathy.
...
...