Apathy and APOE4 are associated with reduced BDNF levels in Alzheimer's disease.

Abstract

Reduced brain-derived neurotrophic factor (BDNF) signaling is considered as a pathogenic event in early Alzheimer's disease (AD), but the influence of apathy and apolipoprotein E ε4 allele (APOE4) on serum BDNF values was not previously investigated in AD. We evaluated serum BDNF levels in AD, amnestic mild cognitive impairment (MCI), and control subjects… (More)
DOI: 10.3233/JAD-140849

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