Apamin induces early afterdepolarizations and torsades de pointes ventricular arrhythmia from failing rabbit ventricles exhibiting secondary rises in intracellular calcium.

@article{Chang2013ApaminIE,
  title={Apamin induces early afterdepolarizations and torsades de pointes ventricular arrhythmia from failing rabbit ventricles exhibiting secondary rises in intracellular calcium.},
  author={Po-Cheng Chang and Yu-Cheng Hsieh and Chia-hsiang Hsueh and James N. Weiss and Shien-fong Lin and P O Chen},
  journal={Heart rhythm},
  year={2013},
  volume={10 10},
  pages={
          1516-24
        }
}
BACKGROUND A secondary rise of intracellular Ca(2+) (Cai) and an upregulation of apamin-sensitive K(+) current (I(KAS)) are characteristic findings of failing ventricular myocytes. We hypothesize that apamin, a specific I(KAS) blocker, may induce torsades de pointes (TdP) ventricular arrhythmia from failing ventricles exhibiting secondary rises of Cai. OBJECTIVE To test the hypothesis that small conductance Ca(2+) activated IKAS maintains repolarization reserve and prevents ventricular… CONTINUE READING
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