Apalutamide: First Global Approval
@article{AlSalama2018ApalutamideFG, title={Apalutamide: First Global Approval}, author={Zaina T. Al-Salama}, journal={Drugs}, year={2018}, volume={78}, pages={699-705} }
Apalutamide (ErleadaTM) is a next-generation oral androgen receptor (AR) inhibitor that is being developed by Janssen for the treatment of prostate cancer (PC). It binds directly to the ligand-binding domain of the AR and blocks the effects of androgens. In February 2018, apalutamide received its first global approval in the USA for the treatment of non-metastatic castration-resistant PC (nmCRPC). Apalutamide is undergoing phase III investigation in chemotherapy-naive patients with metastatic…
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