Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males

@article{ODell1997ApalPI,
  title={Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males},
  author={SD O’Dell and G Miller and J F Cooper and P Hindmarsh and P. Jane Pringle and Henry Ford and S Humphries and I Day},
  journal={International Journal of Obesity},
  year={1997},
  volume={21},
  pages={822-825}
}
In 1474 healthy Caucasoid men aged 45–65 y, insulin-like growth factor II (IGF2) Apal AA homozygotes showed a mean body weight 4 kg lower than Apal GG homozygotes (77.6±10.9 kg vs 81.6±11.5 kg, P=0.003) with heterozygotes (GA) intermediate (80.1±11.9 kg). The mean serum IGF-II concentration in 44 Apal AA individuals was significantly higher than in 48 Apal GG individuals (683.3±146.9 ng/ml vs 614.0±124.0 ng/ml, P=0.01). An INS Pstl polymorphism showed no association with weight and it was also… CONTINUE READING

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Electrophoresis for genotyping : microtitre array diagonal gel electrophoresis ( MADGE ) on horizontal polyacrylamide ( H - PAGE ) gels , Hydrolink or agar

  • Day INM, SE Humphries
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