Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

Abstract

Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian homolog of C. elegans CED-4, was investigated in gene-targeted Apaf1-/- mice. Apaf1-deficient mice exhibited reduced apoptosis in the brain and striking craniofacial abnormalities with hyperproliferation of neuronal cells. Apaf1… (More)
DOI: 10.1016/S0092-8674(00)81733-X

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