• DOI:10.1016/S0092-8674(00)81733-X
Corpus ID: 1096066

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

@article{Yoshida1998Apaf1IR,
  title={Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development},
  author={H. Yoshida and Y. Kong and R. Yoshida and A. Elia and A. Hakem and R. Hakem and J. Penninger and T. Mak},
  journal={Cell},
  year={1998},
  volume={94},
  pages={739-750}
}

H. Yoshida, Y. Kong, +5 authors T. Mak

Published 1998

Biology, Medicine

Cell

Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian homolog of C. elegans CED-4, was investigated in gene-targeted Apaf1-/- mice. Apaf1-deficient mice exhibited reduced apoptosis in the brain and striking craniofacial abnormalities with hyperproliferation of neuronal cells. Apaf1-deficient cells were resistant to a variety of apoptotic stimuli, and the processing of Caspases 2, 3, and 8 was impaired. However, both… CONTINUE READING

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