Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
@article{Yoshida1998Apaf1IR, title={Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development}, author={H. Yoshida and Y. Kong and R. Yoshida and A. Elia and A. Hakem and R. Hakem and J. Penninger and T. Mak}, journal={Cell}, year={1998}, volume={94}, pages={739-750} }
Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian homolog of C. elegans CED-4, was investigated in gene-targeted Apaf1-/- mice. Apaf1-deficient mice exhibited reduced apoptosis in the brain and striking craniofacial abnormalities with hyperproliferation of neuronal cells. Apaf1-deficient cells were resistant to a variety of apoptotic stimuli, and the processing of Caspases 2, 3, and 8 was impaired. However, both… CONTINUE READING
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References
SHOWING 1-10 OF 122 REFERENCES
Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development
- Biology, Medicine
- Cell
- 1998
- 900
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.
- Biology, Medicine
- Genes & development
- 1998
- 860
- PDF
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
- Biology, Medicine
- Nature
- 1996
- 1,907
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
- Biology, Medicine
- Cell
- 1998
- 1,650
- PDF
Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex*
- Medicine, Biology
- The Journal of Biological Chemistry
- 1998
- 545
- PDF
Developmental and genetic regulation of programmed neuronal death.
- Biology, Medicine
- Journal of neural transmission. Supplementum
- 1997
- 21
Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1997
- 232
- PDF
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1998
- 558
- Highly Influential
- PDF
Interaction between the C. elegans cell-death regulators CED-9 and CED-4
- Biology, Medicine
- Nature
- 1997
- 312
- Highly Influential