Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

  title={Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development},
  author={H. Yoshida and Y. Kong and R. Yoshida and A. Elia and A. Hakem and R. Hakem and J. Penninger and T. Mak},
  • H. Yoshida, Y. Kong, +5 authors T. Mak
  • Published 1998
  • Biology, Medicine
  • Cell
  • Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian homolog of C. elegans CED-4, was investigated in gene-targeted Apaf1-/- mice. Apaf1-deficient mice exhibited reduced apoptosis in the brain and striking craniofacial abnormalities with hyperproliferation of neuronal cells. Apaf1-deficient cells were resistant to a variety of apoptotic stimuli, and the processing of Caspases 2, 3, and 8 was impaired. However, both… CONTINUE READING
    1,116 Citations

    Figures, Tables, and Topics from this paper

    The role of Apaf-1 in programmed cell death: from worm to tumor.
    • H. Yoshida
    • Biology, Medicine
    • Cell structure and function
    • 2003
    • 22
    • PDF
    Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulin.
    • 9
    Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors
    • 31
    • PDF
    Mitochondria-mediated apoptosis in mammals
    • 191
    • PDF


    Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.
    • 860
    • PDF
    Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
    • 1,331
    Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
    • 1,650
    • PDF
    Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex*
    • 545
    • PDF
    Developmental and genetic regulation of programmed neuronal death.
    • 21
    Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation.
    • L. Boise, C. Thompson
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1997
    • 232
    • PDF
    Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
    • 558
    • Highly Influential
    • PDF
    Interaction between the C. elegans cell-death regulators CED-9 and CED-4
    • 312
    • Highly Influential