Apaf-1 is a mediator of E2F-1-induced apoptosis.


E2F-1 is capable of promoting both cell cycle progression and apoptosis. The latter is important for suppressing untoward expansion of proliferating cells. In this study, we investigated its underlying mechanisms. E2F-1-induced apoptosis was accompanied by caspase-9 activation and inhibited by a specific inhibitor of caspase-9 in K562 sublines… (More)


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@article{Furukawa2002Apaf1IA, title={Apaf-1 is a mediator of E2F-1-induced apoptosis.}, author={Yusuke Furukawa and Noriko Nishimura and Yutaka Furukawa and Masaaki Satoh and Hitoshi Endo and Satsuki Iwase and Hisashi Yamada and Michio Matsuda and Yasuhiko Kano and Mitsuru Nakamura}, journal={The Journal of biological chemistry}, year={2002}, volume={277 42}, pages={39760-8} }