Apaf-1: Regulation and function in cell death.

  title={Apaf-1: Regulation and function in cell death.},
  author={Raheleh Shakeri and Asma Kheirollahi and Jamshid Davoodi},
Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or unnecessary cells in multicellular organisms. Various types of intracellular stress trigger apoptosis by induction of cytochrome c release from mitochondria into the cytosol. Apoptotic protease activating factor-1 (Apaf-1) is a key molecule in the intrinsic or mitochondrial pathway of apoptosis, which oligomerizes in response to cytochrome c release and forms a large complex known as apoptosome. Procaspase-9… CONTINUE READING
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