Apaf-1/cytochrome c apoptosome: an essential initiatorof caspase activation or just a sideshow?

Abstract

Caspase activation in mammalian cells is mediated via two main routes, often referred to as ‘the intrinsic pathway’ and ‘the extrinsic pathway’. The extrinsic pathway of apoptosis is induced by ligand-mediated activation of the tumour necrosis factor (TNF) family of cell surface receptors. A large protein complex, known as the DISC, forms at the cell… (More)
DOI: 10.1038/sj.cdd.4401166

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