Aortic wall damage in mice unable to synthesize ascorbic acid.

Abstract

By inactivating the gene for L-gulono-gamma-lactone oxidase, a key enzyme in ascorbic acid synthesis, we have generated mice that, like humans, depend on dietary vitamin C. Regular chow, containing about 110 mg/kg of vitamin C, is unable to support the growth of the mutant mice, which require L-ascorbic acid supplemented in their drinking water (330 mg… (More)

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Cite this paper

@article{Maeda2000AorticWD, title={Aortic wall damage in mice unable to synthesize ascorbic acid.}, author={Nobuyo N. Maeda and Hideo Hagihara and Yuichiro Nakata and Sylvia Hiller and Joanna Wilder and Robert Lee Reddick}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2000}, volume={97 2}, pages={841-6} }