Aortic thrombosis in a neonate: failure of urokinase thrombolytic therapy.


Complete aortic occlusion at L2-L3 occurred in an 11-day-old male with hypernatremic dehydration. Attempted thrombolytic therapy using intraarterial urokinase was unsuccessful in inducing either a systemic hyperfibrinolytic state or lysis of the clot. The infant's plasma plasminogen level was low (50-75% of adult levels) and neither fresh frozen plasma nor… (More)


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