Aortic stiffness and left ventricular mass in a rat model of isolated systolic hypertension.

@article{TatchumTalom1995AorticSA,
  title={Aortic stiffness and left ventricular mass in a rat model of isolated systolic hypertension.},
  author={R Tatchum-Talom and Nathalie Niederhoffer and Farooq Amin and T. Makki and P. Tankosic and Julia Atkinson},
  journal={Hypertension},
  year={1995},
  volume={26 6 Pt 1},
  pages={
          963-70
        }
}
We tested whether cardiac mass can be related to decreased aortic stiffness in an original rat model of isolated systolic hypertension. Increased aortic stiffness was produced by calcium overload of elastic arteries after vitamin D3 plus nicotine treatment. Half of the animals were chronically treated with the angiotensin-converting enzyme inhibitor perindopril (1 mg/kg per day PO). Rats were pithed, and lower body vascular resistance was measured. Blood pressure was then increased by… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Influence of estrogen on aortic stiffness and endothelial function in female rats.

  • American journal of physiology. Heart and circulatory physiology
  • 2002
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Elastin in Large Artery Stiffness and Hypertension

  • Journal of Cardiovascular Translational Research
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND