Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice.

@article{Saraff2003AorticDP,
  title={Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice.},
  author={Kiran Y. Saraff and Fjoralba Babamusta and Lisa A. Cassis and Alan Daugherty},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 9},
  pages={
          1621-6
        }
}
OBJECTIVE We sought to define the temporal characteristics of angiotensin II (AngII)-induced abdominal aortic aneurysms (AAAs) and to provide mechanistic insight into the development of this vascular pathology in apolipoprotein E-deficient (apoE-/-) mice. METHODS AND RESULTS Male apoE-/- mice were infused with AngII for 1 to 56 days. Suprarenal arteries were sequentially sectioned, and cellular features were defined by histologic and immunocytochemical techniques. The initial identified event… CONTINUE READING

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