Aorta-associated CD34+ hematopoietic cells in the early human embryo.

  title={Aorta-associated CD34+ hematopoietic cells in the early human embryo.},
  author={Manuela Tavian and Laure Coulombel and Dominique Luton and H. San Cl{\'e}mente and Françoise Dieterlen-Li{\'e}vre and Bruno P{\'e}ault},
  volume={87 1},
Hematopoiesis is established from circulating blood stem cells that seed the embryonic rudiments of blood-forming tissues, a basic notion in developmental hematology. However, the assumption that these stem cells originate from the extraembryonic mesoderm, where primitive hematopoiesis is initiated by intrinsic precursors, has been reconsidered after analysis of blood cell development in avian embryo chimeras: yolk-sac-derived stem cells do not contribute significantly to the definitive blood… CONTINUE READING
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