Anxiolytics not acting at the benzodiazepine receptor: Beta blockers

@article{Tyrer1992AnxiolyticsNA,
  title={Anxiolytics not acting at the benzodiazepine receptor: Beta blockers},
  author={Peter Tyrer},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1992},
  volume={16},
  pages={17-26}
}
  • P. Tyrer
  • Published 31 January 1992
  • Psychology, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Pindolol proved to be just as effective as MPH in decreasing hyperactivity and conduct problems at home, and hyperactivity problems at school, and was modestly effective in the treatment of ADHD.

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An algorithm for GAD treatment is proposed and the main research lines on new anxiolytic drugs and their stage of clinical or pre-clinical development are presented.

Pharmacotherapy for Anxiety Disorders: Using the Available Drugs

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It is a matter of some concern that changes in the National Health Service are increasingly shifting the onus of responsibility for treatment from the psychiatrist to the general practitioner, and it behoves both disciplines to keep liaison active, so that best practice can be maintained from whatever source it is being provided.

The neurobiology and control of anxious states

  • M. Millan
  • Biology, Psychology
    Progress in Neurobiology
  • 2003

β-adrenergic receptors are involved in stress-related behavioral changes

Understanding the Pathophysiology and Management of the Anxiety Disorders

Anxiety is a general psychiatric state characterized by fear, worry, unnecessary violent behavior, poor quality of life, avoidance and the compulsive rituals that are related with the significant

Subchronic treatment with amino acid mixture of L-lysine and L-arginine modifies neuroendocrine activation during psychosocial stress in subjects with high trait anxiety

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Results of the present study support the hypothesis that L-lysine in combination with L-arginine, which may induce anxiolytic effects, modify hormonal responses during psychosocial stress in humans.

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Three different beta-adrenoreceptor antagonists--propranolol, sotalol, and atenolol--were compared in a double-blind study with placebo in patients with essential tremor and results suggest that the reduction in tremor produced by beta- adrenore receptor antagonists is mediated by an effect on peripheral beta 2-adRenoreceptors.

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The results suggest that (+)- and (±)-propranolol have no psychotropic effects on induced anxiety and that their modes of action are fundamentally different from that of diazepam.