Anxiolytics not acting at the benzodiazepine receptor: Beta blockers

  title={Anxiolytics not acting at the benzodiazepine receptor: Beta blockers},
  author={Peter Tyrer},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • P. Tyrer
  • Published 31 January 1992
  • Psychology, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry

Neurobiologic Basis of Anxiety and Its Treatment

New evidence suggests a role for adenosine and cholecystokinin in the development of anxiety; drugs interacting with these neurotransmitters also may have anxiolytic properties.

Pindolol and methylphenidate in children with attention-deficit hyperactivity disorder. Clinical efficacy and side-effects.

Pindolol proved to be just as effective as MPH in decreasing hyperactivity and conduct problems at home, and hyperactivity problems at school, and was modestly effective in the treatment of ADHD.

Tratamento farmacológico do transtorno de ansiedade generalizada: perspectivas futuras

An algorithm for GAD treatment is proposed and the main research lines on new anxiolytic drugs and their stage of clinical or pre-clinical development are presented.

Pharmacotherapy for Anxiety Disorders: Using the Available Drugs

It is a matter of some concern that changes in the National Health Service are increasingly shifting the onus of responsibility for treatment from the psychiatrist to the general practitioner, and it behoves both disciplines to keep liaison active, so that best practice can be maintained from whatever source it is being provided.

The neurobiology and control of anxious states

  • M. Millan
  • Biology, Psychology
    Progress in Neurobiology
  • 2003

β-adrenergic receptors are involved in stress-related behavioral changes

Understanding the Pathophysiology and Management of the Anxiety Disorders

Anxiety is a general psychiatric state characterized by fear, worry, unnecessary violent behavior, poor quality of life, avoidance and the compulsive rituals that are related with the significant

Subchronic treatment with amino acid mixture of L-lysine and L-arginine modifies neuroendocrine activation during psychosocial stress in subjects with high trait anxiety

Results of the present study support the hypothesis that L-lysine in combination with L-arginine, which may induce anxiolytic effects, modify hormonal responses during psychosocial stress in humans.



Propranolol in chronic anxiety disorders. A controlled study.

The beta-adrenergic blocking drug propranolol hydrochloride reduced symptoms in 17 of 26 patients with chronic anxiety disorders and both somatic and psychic symptoms improved as judged by patient and observer ratings.

beta-Adrenoreceptor antagonists in essential tremor.

Three different beta-adrenoreceptor antagonists--propranolol, sotalol, and atenolol--were compared in a double-blind study with placebo in patients with essential tremor and results suggest that the reduction in tremor produced by beta- adrenore receptor antagonists is mediated by an effect on peripheral beta 2-adRenoreceptors.

Oxprenolol in the treatment of anxiety due to environmental stress.

Two trial studies to evaluate the use of oxprenolol in the treatment of symptoms resulting from environmental stress indicated that on a three-times-a-day regimen, 80 mg of ox peregrineol was superior to 20 mg of OxpRenolol and equally as effective as 5 mg of diazepam.

The Effect of Beta Adrenergic Blocking Drugs on Speakers' Performance and Memory

Results were interpreted as showing a central as well as peripheral role for propranolol in blocking adrenergic receptors' activity in anxiety.

Diazepam and propranolol in panic disorder and agoraphobia.

The results suggest that benzodiazepines constitute effective short-term treatment for these newly defined disorders of panic disorder and agoraphobia.

Drug treatment of social phobia.

Physiological and psychological effects of ±-propranolol, +-propranolol and diazepam in induced anxiety.

The results suggest that (+)- and (±)-propranolol have no psychotropic effects on induced anxiety and that their modes of action are fundamentally different from that of diazepam.