Anxiolytic-like profile of propofol, a general anesthetic, in the plus-maze test in mice.

@article{Kurt2003AnxiolyticlikePO,
  title={Anxiolytic-like profile of propofol, a general anesthetic, in the plus-maze test in mice.},
  author={Mehmet Emin Kurt and S. Sırrı Bilge and Osman Kukula and Suleyman Burak Celik and Yuksel Kesim},
  journal={Polish journal of pharmacology},
  year={2003},
  volume={55 6},
  pages={973-7}
}
The present study was performed to investigate the effect of propofol on anxiety using the elevated plus-maze test. Groups of mice received propofol (20, 40, 60 mg/kg) or diazepam (2 mg/kg), caffeine (30 mg/kg), L-arginine (100 mg/kg), m-chlorophenylpiperazine (m-CPP, 2.5 mg/kg) and then were placed in an elevated plus-maze that was composed of two opposite closed arms and two opposite open arms. Propofol (20, 40, 60 mg/kg) and diazepam (2 mg/kg) significantly increased the percentage of time… CONTINUE READING

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Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology • 2002
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