Anxiolytic-like effects of antidepressants after acute administration in a four-plate test in mice.

@article{Hascet2000AnxiolyticlikeEO,
  title={Anxiolytic-like effects of antidepressants after acute administration in a four-plate test in mice.},
  author={Martine Hasc{\"o}et and Michel S Bourin and Marie Claude Colombel and Alexandra J. Fiocco and Glen B Baker},
  journal={Pharmacology, biochemistry, and behavior},
  year={2000},
  volume={65 2},
  pages={339-44}
}
The four-plate test (FPT) is an animal model of anxiety based on stress caused by unconditioned fear. An increase of spontaneous punished behavior was used as a measure to determine the anxiolytic effects of various antidepressants (ADs). In the present study. ADs with different mechanisms of action, including tricyclics, selective serotonin reuptake inhibitors (SSRIs), a monoamine oxidase inhibitor (MAOI), and atypicals, were studied in the FPT to evaluate their anxiolytic-like effects… CONTINUE READING