Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats.

@article{Stachowicz2004AnxiolyticlikeEO,
  title={Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats.},
  author={Katarzyna Stachowicz and Kinga Kłak and Aleksandra Kłodzińska and Ewa Chojnacka-W{\'o}jcik and Andrzej Pilc},
  journal={European journal of pharmacology},
  year={2004},
  volume={498 1-3},
  pages={
          153-6
        }
}
We examined the potential anxiolytic-like activity of (-)-N-phenyl-7-(hydroxyimino) cyclopropa[b]chromen-1a-carboxamide (PHCCC), an allosteric modulator of metabotropic glutamate4 receptors (mGlu4), after administration into the basolateral amygdala, using the conflict drinking Vogel test in rats as a model. The results indicate that PHCCC, but not 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt), the selective antagonist of group mGlu1 receptors, showed significant… CONTINUE READING

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