Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray.

@article{Moreira2007AnxiolyticlikeEO,
  title={Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray.},
  author={Fabricio A Moreira and Daniele Cristina Aguiar and Francisco S Guimar{\~a}es},
  journal={Neuropharmacology},
  year={2007},
  volume={52 3},
  pages={958-65}
}
Contradictory results exist concerning the effects of systemic injections of CB(1) cannabinoid receptor agonists on anxiety-related behaviors. Direct drug administration into brain structures related to aversive responses can potentially help to clarify the role of cannabinoids on anxiety. One such structure is the midbrain dorsolateral periaqueductal gray (dlPAG). Therefore, the aim of this study was to test the hypothesis that the activation of the CB(1) receptor in the dlPAG would attenuate… CONTINUE READING
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