Anxiolytic-like behavior after lesion of the tuberomammillary nucleus E2-region

@article{Frisch1998AnxiolyticlikeBA,
  title={Anxiolytic-like behavior after lesion of the tuberomammillary nucleus E2-region},
  author={Christian Frisch and R{\"u}diger U Hasen{\"o}hrl and Joachim Krauth and Joseph P. Huston},
  journal={Experimental Brain Research},
  year={1998},
  volume={119},
  pages={260-264}
}
The tuberomammillary nucleus (TM), located in the posterior hypothalamic region, consists of five subgroups and is the only known source of brain histamine. In the present experiment, rats received bilateral ibotenic acid or sham lesions in the rostroventral part of the TM (E2-region). Three weeks later they were tested on the elevated plus-maze test of fear and anxiety. Lesions in the tuberomammillary E2-region elevated the time spent on the open arms, as well as excursions into the end of the… CONTINUE READING

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