Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants.

@article{Lotarski2011AnxiolyticlikeAO,
  title={Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants.},
  author={Susan M Lotarski and Sean Donevan and Ayman El-Kattan and Sarah M Osgood and Julie Poe and Charles P Taylor and James Offord},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={338 2},
  pages={615-21}
}
The α(2)δ auxiliary subunits (α(2)δ-1 and α(2)δ-2) of voltage-sensitive calcium channels are thought to be the site of action of pregabalin (Lyrica), a drug that has been shown to be anxiolytic in clinical trials for generalized anxiety disorder. Pregabalin and the chemically related drug gabapentin have similar binding and pharmacology profiles, demonstrating high-affinity, in vitro binding to both α(2)δ-1 and α(2)δ-2 subunits. Two independent point mutant mouse strains were generated in which… CONTINUE READING
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Sensitivity to pregabalin and diazepam in five inbred mouse strains in the vogel conflict test, in Program No. 115.5

  • SM Lotarski, JJ Kinsora
  • 2004
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