Anxiolytic-like activity and GC–MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants

@article{Lima2013AnxiolyticlikeAA,
  title={Anxiolytic-like activity and GC–MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants},
  author={Naiana G. P. B. Lima and Dami{\~a}o P Sousa and Fl{\'a}via Cristina Fernandes Pimenta and Mateus Feitosa Alves and F{\'a}bio Suano de Souza and Rui Oliveira Mac{\^e}do and Ricardo B. Cardoso and Liana Cl{\'e}bia S.L. de Morais and Margareth de F{\'a}tima Formiga de Melo Diniz and Reinaldo N{\'o}brega de Almeida},
  journal={Pharmacology Biochemistry and Behavior},
  year={2013},
  volume={103},
  pages={450-454}
}
The traditional use of essential oils in aromatherapy has offered numerous health benefits. However, few scientific studies have been conducted with these oils to confirm their therapeutic efficacy. (+)-Limonene is a chemical constituent of various bioactive essential oils. The present study reports on the anxiolytic-like effects of (+)-limonene in an elevated maze model of anxiety in mice. At concentrations of 0.5% and 1.0%, (+)-limonene, administered to mice by inhalation, significantly… CONTINUE READING
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