Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated

@article{Kennett1998AnxiolyticlikeAO,
  title={Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated},
  author={Guy A. Kennett and Brenda K Trail and F. Bright},
  journal={Neuropharmacology},
  year={1998},
  volume={37},
  pages={1603-1610}
}
The 5-HT2B receptor agonist, BW 723C86 (10, 30(mg/kg i.p. 30 min pre-test), increased the number of punishments accepted in a rat Vogel drinking conflict paradigm over 3 min, as did the benzodiazepine anxiolytics, chlordiazepoxide (2.5-10 mg/kg p.o. 1 h pre-test) and alprazolam (0.2-5 mg/kg p.o. 1 h pre-test), but not the 5-HT2C/2B receptor agonist, m-chlorophenylpiperazine (mCPP, 0.3-3 mg/kg i.p) or the 5-HT1A receptor agonist, buspirone (5-20 mg/kg p.o. 1 h pre-test). The effect of BW 723C86… Expand
Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety
TLDR
Behavioural results are indicative of an anxiolytic-like action of 5-HT(2) receptor agonists, an anxiogenic-like effect of 5 (2A) receptor antagonism, whereas the blockade of 5(2C) receptors are without effect in the mouse models studied. Expand
The effects of compounds varying in selectivity as 5-HT1A receptor antagonists in three rat models of anxiety
TLDR
The present results demonstrate that 5-HT(1A) receptor antagonists elicit anxiolytic-like effects in rats, and this action appears to be test-specific and, unlike previous findings in mice, smaller than that observed with benzodiazepines. Expand
Effects of RO 60 0175, a 5-HT(2C) receptor agonist, in three animal models of anxiety.
TLDR
The effects of the novel 5-HT(2C) receptor agonist, RO 60 0175, in three models of anxiety were tested, and it was found to induce hypolocomotion in rats at doses greater than 0.5 mg/kg s.c, but was neither anxiolytic, nor clearly anxiogenic at the doses tested. Expand
Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding
TLDR
The results indicate distinct, and in some cases opposite, effects of a 5-HT2A compared with a 5,HT2C receptor antagonist on various cocaine-mediated behavioral effects. Expand
The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism
TLDR
The results suggest that 5-HT2A receptor antagonists may normalise certain 'impulsive' behaviours produced by NMDA receptor hypofunction, as well as attenuate the hyperlocomotion and stereotypy produced by dizocilpine. Expand
Implication of 5-HT2A subtype receptors in DOI activity in the four-plates test–retest paradigm in mice
TLDR
In the FPT test-retest paradigm, which 5-HT(2) receptor subtype(s) was involved in the DOI-induced effect in experienced mice is investigated, suggesting that DOI exerts its anxiolytic-like effect in the F PT test- retest paradigm through 5- HT(2A) receptors. Expand
Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents
TLDR
The results demonstrate that the novel 5-HT2C receptor agonist WAY-163909 produces rapid onset antidepressant-like effects in animal models and may be a novel treatment for depression. Expand
The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats
TLDR
Probably reflecting its distinctive ability to selectively and preferentially activate pre- versus postsynaptic 5-HT1A receptors, S15535 suppresses hippocampal 5- HT release and displays marked anxiolytic-like effects over a broad dose range in the relative absence of motor perturbation. Expand
Modulation of 5-HT2A receptor-mediated head-twitch behaviour in the rat by 5-HT2C receptor agonists
The pharmacology of several commonly described 5-hydroxytryptamine (5-HT)2C receptor agonists was investigated in vivo and in vitro at rat 5-HT2A, 5-HT2B, and 5-HT2C receptors. The 5-HT2C receptorExpand
Opposing effects of 5-HT2A and 5-HT2C receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test
TLDR
Serotonin exerts both excitatory and inhibitory influences on motor impulsivity via 5- HT2A and 5-HT2C receptors in both rats and mice. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Effects of the 5‐HT2B receptor agonist, BW 723C86, on three rat models of anxiety
TLDR
In conclusion, BW 723C86 exerted an appreciable anxiolytic‐like profile in a rat social interaction test, but had a weaker effect in the Geller‐Siefter and was ineffective in the elevated x‐maze test used. Expand
BW 723C86, a 5-HT2B Receptor Agonist, Causes Hyperphagia and Reduced Grooming in Rats
TLDR
Behaviour associated with administration of the 5-HT2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) did not cause hypolocomotion, penile erection, oral dyskinesias or hyperthermia, behaviours associated with Administration of the5-HT1A receptor antagonist WAY 100635, and are thus likely to involve-5- HT2C receptor activation. Expand
Activation of 5-HT2B Receptors in the Medial Amygdala causes Anxiolysis in the Social Interaction Test in the Rat
TLDR
Bilateral micro-injection of the 5-HT2B receptor agonist into the medial amygdaloid nuclei increased the total interaction time of a pair of male rats in the social interaction test, to a comparable extent to chlordiazepoxide without altering locomotor activity; indicative of anxiolytic activity. Expand
SB 242084, a Selective and Brain Penetrant 5-HT2C Receptor Antagonist
TLDR
The results suggest that SB 242084 is the first reported selective potent and brain penetrant 5- HT2C receptor antagonist and has anxiolytic-like activity, but does not possess either proconvulsant or hyperphagic properties which are characteristic of mutant mice lacking the 5-HT2C receptors. Expand
Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist
TLDR
In vitro electrophysiological studies demonstrated that WAY-100635 had no 5-HT1A receptor agonist actions, but dose-dependently blocked the effects of agonists at both the postsynaptic5-HT 1A receptor in the CA1 region of the hippocampus, and the somatodendritic 5-ht1A receptors located on dorsal raphe 5- HT neurones. Expand
5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research.
  • G. Griebel
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 1995
TLDR
Observations lead to the conclusion that different 5-HT mechanisms, mediated by different receptor subtypes, are involved in the genesis of anxiety. Expand
Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam
TLDR
Results suggest that an interaction with 5‐HT1A receptors is the basis of the anxiolytic‐like activity of MDL 73005EF, however, its mechanism of action is clearly different from that of buspirone, possibly reflecting a greater selectivity for the 5‐ HT1A receptor located presynaptically on central 5‐hydroxytryptaminergic neurones. Expand
In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties
TLDR
The results suggest that SB 206553 is a potent mixed 5‐HT2C/5-HT2B receptor antagonist with selectivity over the 5‐ HT2A and all other sites studied and possesses anxiolytic‐like properties. Expand
Septal lesions inhibit fear reactions in two animal models of anxiolytic drug action
TLDR
Results provide convergent evidence that posterior regions of the septum play an important role in the control of anxiety in the rat. Expand
The neuroanatomical specificity of the anxiolytic effects ofintra-septal infusions of midazolam
TLDR
The results suggest that the anxiolytic effects of intra-septal midazolam occur, at least in part, at GABAA-benzodiazepine receptor sites located in the lateral septal nuclei. Expand
...
1
2
...