Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated

  title={Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated},
  author={Guy A. Kennett and Brenda K Trail and F. Bright},

The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism

The results suggest that 5-HT2A receptor antagonists may normalise certain 'impulsive' behaviours produced by NMDA receptor hypofunction, as well as attenuate the hyperlocomotion and stereotypy produced by dizocilpine.

Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents

The results demonstrate that the novel 5-HT2C receptor agonist WAY-163909 produces rapid onset antidepressant-like effects in animal models and may be a novel treatment for depression.

Opposing effects of 5-HT2A and 5-HT2C receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test

Serotonin exerts both excitatory and inhibitory influences on motor impulsivity via 5- HT2A and 5-HT2C receptors in both rats and mice.



Effects of the 5‐HT2B receptor agonist, BW 723C86, on three rat models of anxiety

In conclusion, BW 723C86 exerted an appreciable anxiolytic‐like profile in a rat social interaction test, but had a weaker effect in the Geller‐Siefter and was ineffective in the elevated x‐maze test used.

Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

Results suggest that an interaction with 5‐HT1A receptors is the basis of the anxiolytic‐like activity of MDL 73005EF, however, its mechanism of action is clearly different from that of buspirone, possibly reflecting a greater selectivity for the 5‐ HT1A receptor located presynaptically on central 5‐hydroxytryptaminergic neurones.

In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties

The results suggest that SB 206553 is a potent mixed 5‐HT2C/5-HT2B receptor antagonist with selectivity over the 5‐ HT2A and all other sites studied and possesses anxiolytic‐like properties.