Anxiolytic-like Actions of the Selective 5-HT4 Receptor Antagonists SB 204070A and SB 207266A in Rats

@article{Kennett1997AnxiolyticlikeAO,
  title={Anxiolytic-like Actions of the Selective 5-HT4 Receptor Antagonists SB 204070A and SB 207266A in Rats},
  author={Guy A. Kennett and F. Bright and Thomas P Blackburn and Graham J Sanger},
  journal={Neuropharmacology},
  year={1997},
  volume={36},
  pages={707-712}
}

Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands

The administration of 5-HT2/3/4 subtype antagonists all generated behavioral profiles indicative of anxiolytic-like effects in the EZM, which was apparent from examination of both traditional and ethological measures.

Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands rats

The administration of 5-HT 2/3/4 subtype antagonists all generated behavioral profiles indicative of anxiolytic-like effects in the EZM, which was apparent from examination of both traditional and ethological measures.

Increased defecation during stress or after 5‐hydroxytryptophan: selective inhibition by the 5‐HT4 receptor antagonist, SB‐207266

It is concluded that selective 5‐ HT4 receptor antagonism prevents disruptions in defecation behaviours caused by exogenous or endogenous enteric 5‐HT and that this activity is not accompanied by a concomitant suppression of activity (constipation‐like) within the intestine itself.

Antagonism of 5-Hydroxytryptamine4 Receptors Attenuates Hyperactivity Induced by Cocaine: Putative Role for 5-Hydroxytryptamine4 Receptors in the Nucleus Accumbens Shell

The data suggest that 5-HT4 receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.

Anti-Anxiety Effects of Prelimbic 5-HT4 Receptors in the Rat Model of Parkinson’s Disease: Evidence from Behavioral and Electrophysiological Study

PrL 5-HT4 receptors regulate anxiety behaviors in PD rats, and its mechanism may be related to the down-regulation of expression or function of PrL 5 -HT4 receptor in PD.
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