Anxiolytic effects of dotarizine, a possible antimigraine drug.

  title={Anxiolytic effects of dotarizine, a possible antimigraine drug.},
  author={Valentin Petkov and Stiliana Belcheva and Elena Konstantinova},
  journal={Methods and findings in experimental and clinical pharmacology},
  volume={17 10},
In experiments on rats in elevated plus-maze and in Opto Varimex apparatus, used for studying exploratory behavior, we observed that dotarizine (DOT), a drug with Ca2+ and 5-HT1/5-HT2-receptor antagonistic action, exerted effects suggesting anxiolytic action. The 5-HT uptake inhibitor fluoxetine (FLU) produced mainly anxiogenic effects. The simultaneous… CONTINUE READING