Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey

@article{Guimares2005AnxiolyticEI,
  title={Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey},
  author={Francisco Silveira Guimar{\~a}es and Antonio P. Carobrez and J. C. de Aguiar and Frederico Guilherme Graeff},
  journal={Psychopharmacology},
  year={2005},
  volume={103},
  pages={91-94}
}
In order to localise the often reported anxiolytic action of N-methyl-D-aspartate (NMDA) receptor antagonists, 2-amino-7-phosphonoheptanoic acid (AP7) was injected into the dorsal periaqueductal grey (DPAG) of rats exposed to the elevated plus-maze model of anxiety. Doses of 0.2, 2 and 20 nmol AP7 caused a dose-dependent increase in the percentage of open arm entries, the effect of the last two doses being significantly different from control. A non-significant tendency to increase the… 
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Microinjection of propranolol into the dorsal periaqueductal gray causes an anxiolytic effect in the elevated plus-maze antagonized by ritanserin
TLDR
The present as well as previously reported results suggest that the anxiolytic effect of propranolol injected into the DPAG is due to increased release of 5-HT acting on post-synaptic 5- HT2 receptors, resultant from blockade of5-HT1B autoreceptors that inhibit amine release from serotonergic nerve endings.
Role of benzodiazepine receptors located in the dorsal periaqueductal grey of rats in anxiety
TLDR
The results showed that midazolam, a BZD agonist, dose-dependently increased the percentage of entries and time spent in open arms when microinjected into the DPAG, and suggest that theDPAG is not the only structure responsible for the anxiolytic effects of systemically injected BZd.
Role of Ventral Hippocampal GABAA and NMDA Receptors in the Anxiolytic Effect of Carbamazepine in Rats Using the Elevated Plus Maze Test
TLDR
The anxiolytic-like effects of CBZ seem to be mediated, at least in part, through an interaction with GABAA and NMDA systems in the VH, which play a role in modulation of anxiety-like behavior of rats.
Anxiolytic effect of spermine microinjected into the dorsal periaqueductal grey in rats
TLDR
Results indicate that the spermine receptor interaction in the modulation of anxiety in rats exposed to the elevated plus-maze, and suggest that polyamine system within DPAG may play a role in aversion and anxiety.
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